Galectins as Adaptors: Linking Glycosylation and Metabolism with Extracellular Cues
نویسندگان
چکیده
منابع مشابه
Myosin VI and its cargo adaptors - linking endocytosis and autophagy.
The coordinated trafficking and tethering of membrane cargo within cells relies on the function of distinct cytoskeletal motors that are targeted to specific subcellular compartments through interactions with protein adaptors and phospholipids. The unique actin motor myosin VI functions at distinct steps during clathrin-mediated endocytosis and the early endocytic pathway - both of which are in...
متن کاملGalectins as Cancer Biomarkers
Galectins are a group of proteins that bind β-galactosides through evolutionarily conserved sequence elements of the carbohydrate recognition domain (CRD). Proteins similar to galectins can be found in very primitive animals such as sponges. Each galectin has an individual carbohydrate binding preference and can be found in cytoplasm as well as in the nucleus. They also can be secreted through ...
متن کاملArchitectural Styles as Adaptors 1
The essence of architectural styles is component communication. In this paper, we relate architectural styles to adaptors in the GenVoca model of software construction. GenVoca components are refinements that have a wide range of implementations, from binaries to rule-sets of program transformation systems. We explain that architectural styles can (1) be understood as refinements (like other Ge...
متن کاملNetrins: versatile extracellular cues with diverse functions.
Netrins are secreted proteins that were first identified as guidance cues, directing cell and axon migration during neural development. Subsequent findings have demonstrated that netrins can influence the formation of multiple tissues, including the vasculature, lung, pancreas, muscle and mammary gland, by mediating cell migration, cell-cell interactions and cell-extracellular matrix adhesion. ...
متن کاملAn improved model framework linking the extracellular environment to antibody glycosylation
Background Glycoproteins make up the bulk of biologically-derived medicines, and are taking up an ever increasing share of the prescription pharmaceuticals market. As opposed to small molecule drugs, glycoproteins are large complex molecules with heterogeneity arising from a multitude of glycan moieties. Glycans are complex post-translation modifications, which result from a number of enzymatic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Glycoscience and Glycotechnology
سال: 2018
ISSN: 0915-7352,1883-2113
DOI: 10.4052/tigg.1732.1se